LEFT VENTRICULAR RELAXATION IS IMPAIRED IN SUBJECTS WITH LV CONCENTRIC REMODELING

Left ventricular concentric geometry is associated with impaired relaxation in hypertension: the HyperGEN study.

AIMS We tested the hypothesis that abnormal left ventricular (LV) relaxation is associated with concentric LV geometry. METHODS AND RESULTS Doppler LV filling properties were studied in 1384 hypertensive participants without cardiovascular disease, from the HyperGEN population (731 women, 784 obese, 236 diabetic) and compared in four LV geometry groups; normal, concentric remodelling (3.5%), ...

Reduced Left Ventricular Torsion Early After Myocardial Infarction is Related to Left Ventricular Remodeling Running title : LV torsion in AMI

Background-Left ventricular (LV) torsion is emerging as a sensitive parameter of LV systolic myocardial performance. Aim of the present study was to explore the effects of acute myocardial infarction (AMI) on LV torsion, and to determine the value of LV torsion early after AMI in predicting LV remodeling at 6-month follow-up. Methods and Results-A total of 120 patients with first ST-elevation A...

Left ventricular concentric remodeling rather than left ventricular hypertrophy is related to the insulin resistance syndrome in elderly men.

BACKGROUND Associations between left ventricular (LV) geometry and the insulin resistance syndrome have been found, mostly in small studies of middle-aged hypertensives. The purpose of this study was to elucidate these associations through the use of a large sample of elderly men. METHODS AND RESULTS We investigated 475 men (157 hypertensives) 71 years of age who were attending a population-b...

Myosin Cross-Bridge Dynamics in Patients With Hypertension and Concentric Left Ventricular Remodeling Donaldson et al: Cross-Bridge Dynamics in LV Remodeling

Myosin cross-bridge dynamics in patients with hypertension and concentric left ventricular remodeling.

BACKGROUND Hypertension (HTN) causes concentric left ventricular remodeling, defined as an increased relative wall thickness or overt left ventricular hypertrophy, and associated diastolic dysfunction. HTN and concentric remodeling are also common precursors to heart failure with a preserved ejection fraction. It is not known whether the myofilament contributes to diastolic dysfunction in patie...